Abstract: Objective To investigate the expression of olfactory mediator 4 (OLFM4), vascular endothelial growth factor (VEGF), and microRNA-124 (miR-124) in cervical cancer (CC) and cervical precancerous lesions (CIN) and their clinical significance. 
Methods A total of 82 specimens of patients with CC undergoing surgical treatment in our hospital were selected as the CC group, 82 cases of CIN specimens were selected as the CIN group during the same period, and 82 cases of normal cervical tissue specimens were selected as the normal group. The 3 groups and the CC group were compared for VEGF,OLFM4, and miR-124 expression in tissue specimens of patients with different pathological parameters. Spearman correlation analysis was used to explore the relationship between the expression of various indicators in the tissues and the pathological parameters of the CC group, and the expression of various indicators in the tissue specimens of CC patients with different prognosis (recurrence) was observed; The value of various indicators in predicting the recurrence was analyzed. 
Results The positive expression rate of VEGF and OLFM4 in CC group was higher than that in CIN group and normal group, while the expression level of miR-124 was lower than that in CIN group and normal group (P＜0.05). The positive rates of VEGF, OLFM4, and miR-124 expression were significantly different in patients with different stages, differentiation degree and recurrence (P＜0.05). The area under the receiver operating characteristic (ROC) curve (AUC)of VEGF, OLFM4 and miR-124 in predicting the recurrence was 0.820, 0.895 and 0.852, respectively, and the AUC of combined detection of VEGF, OLFM4 and miR-124 in prediction was 0.945, which was significantly higher than that of each indicator alone. 
Conclusion The positive rate of VEGF and OLFM4 in cancer tissues of CC patients is significantly higher and the expression level of miR-124 is lower. The expression of each indicator is associated with the biological behavior of CC, which could be used to effectively assess tumor proliferation and invasion and to predict postoperative recurrence. 

Key words: uterine cervical neoplasms, precancerous lesions, vascular endothelial growth factor