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Table of Content

    25 February 2018, Volume 39 Issue 2
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    A crosssection study of benefiting people with statin therapy by application of 10year ASCVD risk assessment method for adults#br#
    NIE Ying1, CHEN Baoxia2*, FENG Xinheng2, XIA Ronghui1, QIU Wenfeng1, SUN Yahui1
    2018, 39(2):  129-132.  doi:10.3969/j.issn.10073205.2018.02.002
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    ［Abstract］ Objective〖HTSS〗〓To carry out a crosssection study in community resident by application the 10year atherosclerotic cardiovascular disease（ASCVD）risk assessment method and then to explore the situation of 4 statin benefit groups.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓
    Application of the risk assessment mothod was recommended by ACC/AHA in 2013. A total of 3 516 individuals with integrated data were studied. 1 891 individuals were calculated for the 10year ASCVD risk. Then the distribution of 4 statin benefit groups and the situation of an estimated 10year ASCVD risk of 7.5% or higher were respectively found.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓Seven hundred and fiftyone patients were benefited from four statin treatments in the community. There were 418 cases with 10 years the risk of ASCVD more than 7.5%.  These people accounted for 21.36% and 11.89% of the total number of candidates. In these 10 years the risk of ASCVD≥ 7.5%, 60-69 years of age accounted for the highest proportion of 49.1%. The score of ASCVD in males was statistically higher than that in females（P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The prevalence of statin benefit community individuals and 10year atherosclerotic ASCVD risk of 7.5% or higher in adult were very high. The score of risk estimation in male was more serious than in female.
    Clinical study of etoposide plus cisplatin combined with different time radiotherapy in the treatment of limitedstage small cell lung cancer#br#
    LI Chen1， HONG Yang2， YANG Xiaoguang3， CAO Liang1， XIANG Baoli1*
    2018, 39(2):  133-136,141.  doi:10.3969/j.issn.10073205.2018.02.003
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    ［Abstract］〓Objective〖HTSS〗〓To compare the benefits and tolerance of radiotherapy patients with limitedstage small cell lung cancer(LSSCLC) in different EP cycles, and to explore the timing of radiotherapy.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The patients with limited stage small cell lung cancer confirmed by pathology were randomly divided into two groups. Group A: VP16 120 mg/m2 d1, 2, 3, cisplatin 60 mg/m2 d1, every 3 weeks for 1 cycles, a total of 4 cycles. In first cycles of concurrent radiotherapy, radiotherapy dose and schedule: 45 GY(1.5 GY, bid) for three weeks. Group B: VP16 120 mg/m2 d1, 2, 3, cisplatin 60 mg/m2 d1, every 3 weeks for 1 cycles, a total of 4 cycles. In second cycles of concurrent radiotherapy, radiotherapy dose and schedule: 45 GY(1.5 GY, bid) for three weeks. Each group received intravenous granisetron and antiemetic therapy 30 minutes before the treatment.The observation indexes were remission rate(RR), disease control rate(DCR), progression free survival(PFS), and the adverse reactions of circulating tumor cells(CTC) number.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The RR and DCR of group A and group B were not statistically significant(P>0.05). The PFS and average survival time of group A were longer than gruop B, the difference was statistically significant(P＜005). In the adverse reactions, the incidence of esophagitis in group A was significantly higher than that in group B(P＜005), and the incidence of leukopenia, anemia and thrombocytopenia were similar in both groups, and the incidence of esophagitis in group A was significantly higher than that in group B(P>0.05). CTC was measured in fourth cycle, the number of CTC in group A was significantly lower than that before chemotherapy(P＜005), the number of CTC in patient with CTC≥10 and CTC≥50 is significantly lower than befor in gruop B, but the number of CTC in patient with CTC≥1 and CTC≥5 was not lower than before(P>0.05). The number of CTC≥5 and CTC≥10 in group A was less than that in group B(P＜005). There was no significant difference between CTC≥1 and CTC≥50 in group A(P> 0.05).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The EP regimen of the first cycle combined with concurrent radiotherapy is superior to EP regimen in the second cycle of combined radiotherapy.
    Analysis of clinical risk factors for readmission in maintenance hemodialysis patients
    SONG Qiong1, WU Rong2, LI Jianhua2*
    2018, 39(2):  137-141.  doi:10.3969/j.issn.10073205.2018.02.004
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    ［Abstract］〓Objective〖HTSS〗〓To analyze the clinical risk factors of readmission within 6months among patients on maintenance hemodialysis for chronic renal failure so as to provide guidance for clinical prevention.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 83 hemodialysis patients were enrolled in the study. The patients were divided into readmission group and nonreadmission group according to whether there were two or more hospital admissions within 6months. The clinical data of all patients were retrospectively analyzed to identify readmission risk factors.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓Among 83 patients, 42(50.6%) had a 6months hospital readmission. The readmission group had 14(33.3%) patients of cardiovascular complications, 11(26.2%) patients of infection, 8(19.0%) patients of digestive tract symptoms, 5(11.9%) patients of poor vascular access, 2(4.8%) patients of respiratory failure, 2(4.8%) patients of stroke. The utilization rate of central venous catheter in the readmission group was higher than that in the nonreadmission group. The proportion of medical insurance between urban and rural residents in the readmission group was higher than that in the nonreadmission group. The admission hemoglobin level was lower than that of the nonreadmission group, and the levels of admission serum phosphorus, Nterminal pro brain natriuretic peptide, hypersensitivity C reactive protein were higher than those of the non readmission group. The discharge hemoglobin and albumin levels were lower than those of the non readmission group, the difference was statistically significant(P<0.05). The logstic regression analysis indicated that the risk factors for the readmission included vascular access, Nterminal pro brain natriuretic peptide, hypersensitivity C reactive protein, and the protective factors included discharge hemoglobin.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The readmission rate was 50.6% in 6months in the maintenance hemodialysis patients, and the major causes of readmission were cardiovascular complications and infection. The risk factors for readmission include vascular access, Nterminal pro brain natriuretic peptide, hypersensitivity C reactive protein and discharge hemoglobin levels. The risk factors of readmission are influenced by many factors. Comprehensive intervention should be carried out according to the risk factors to reduce the incidence of readmission and improve the quality of life of patients.
    Trentment effect of intracranial pressure monitoring ventricle drainage combined with lumbar puncture in treatment of craniocerebral injury patients with traumatic subarachnoid hemorrhage #br#
    GUO Wei， HAO Liang， ZHANG Lihua， JIA Weixian， YAO Zhigang， SUN Xiaoli
    2018, 39(2):  142-145.  doi:10.3969/j.issn.10073205.2018.02.005
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    ［Abstract］ Objective〖HTSS〗〓To observe the trentment effect of intracranial pressure monitoring ventricle drainage combined with lumbar puncture in treatment of craniocerebral injury patients with traumatic subarachnoid hemorrhage patients.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and sevety patients with traumatic subarachnoid hemorrhage were randomly divided into two groups, 91 patients with intracranial pressure monitoring ventricle drainage combined with lumbar puncture as the treatment group and 79 patients received conservative treatment as control group. To observe the incidence rate of two groups of patients with cerebral vasospasm, cerebral infarction, traumatic hydrocephalus, cerebral hernia and 6 months Glasgow Prognostic Scale were compared.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The incidence of cerebral vasospasm,cerebral infarction, cerebral hernia and traumatic hydrocephalus in the treatment group was significantly lower than that in the control group（P＜005）. The treatment group Glasgow Prognosis Scale recovery rate was higher than those of control group, which had significant difference (P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Intracranial pressure monitoring ventricle drainage combined with lumbar puncture can significantly reduce the incidence of complications and improve the quality of life of the craniocerebral injury patients with traumatic subarachnoid hemorrhage.
    Comparison of the safety and therapeutic effect of minimally invasive esophagectomy and routine thoracotomy in the treatment of esophageal cancer#br#
    RONG Yu, HAO Yanbing, LI Yanming, WEI Dong, CHEN Wansheng
    2018, 39(2):  146-149,154.  doi:10.3969/j.issn.10073205.2018.02.006
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    ［Abstract］〓Objective〖HTSS〗〓To investigate the safety and therapeutic effect of minimally invasive esophagectomy(MIE) for esophageal cancer.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and twentythree cases of esophageal cancer in stage 0-Ⅲb were divided into MIE group with 68 cases and conventional thoracic surgery group with 55 cases according to their wishes. Operation time, bleeding volume, drainage volume of thoracic, chest drainage tube placement time, the time of beginning taking food, the level of post operation pain, the number of lymph node dissection and incidence of complications were compared between the two groups. Oneyear diseasefree survival rate and oneyear overall survival rate were analyzed.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The MIE group had significantly higher operation time, less bleeding volume, less chest drainage volume，shorter drainage tube placement time，shorter beginning taking food time，lighter operative pain，more number of the lymph node dissection than the conventional thoracic surgery group(P＜005). The incidence of postoperative pulmonary infection in MIE group were lower than the conventional thoracic surgery group（P＜005）. The incidence rate of anastomotic fistula, empyema, chylothorax, hoarseness and anastomotic stenosis had no statistics significancebetween the two groups（P＞005）. Oneyear diseasefree survival rate in MIE group was higher than the conventional thoracic surgery group(P＜005) and oneyear overall survival rate had no statistics significancebetween the two groups（P＞005）.
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The MIE has smaller damage and higher safety than conventional thoracic surgery, and it also can improve the diseasefree survival rate.
    Effects of recombinant human natriuretic peptide on the postoperative BNP, cTnI and LVEF of offpump coronary artery bypass patients#br#
    SONG Shutian, WANG Yutong, ZHOU Jiwu, BAI Chuanming, YANG Ming
    2018, 39(2):  150-154.  doi:10.3969/j.issn.10073205.2018.02.007
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    ［Abstract］〓Objective〖HTSS〗〓To observe the effects of the recombinant human brain natriuretic peptide (rhBNP) on the postoperative brain natriuretic peptide (BNP), cardiac troponin I(cTnI) and left ventricular ejection fraction (LVEF) of the offpump coronary artery bypass grafting(OPCABG).
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 103 cases of OPCABG in our hospital were randomly divided into the rhBNP and the control group, including 52 of the rhBNP group and 51 in the control group. Before operation, immediately after operation(before medicinal), 24 h after operation, 48 h after operation,and 7 days after operation, the blood was extracted to detect the BNP and the cTnI and cardiac color doppler uhrasonography was examined to check up LVEF.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The difference between the two groups patients of saphenous bypass graft was statistically significant(P＞005). cTnI and the BNP of the two groups were increased first and then decreased, and the peak value of cTnI was at 24 h after the operation. The peak value of BNP was at 48 h after operation, and the variation of rhBNP group was less than that of the control group. The LVEF of 2 groups showed a trend of decreasing first and then increasing. The lowest value was at 48 h after operation, and the rhBNP group was higher than that of the control group. There was significant difference in interaction between group, time point and group point(P<0.05). There was no statistically significant difference in cardiovascular events between the two groups(P＞005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The OPCABG postoperative application of rhBNP can reduce the release of endogenous BNP and cTnI. RhBNP can be used to improve postoperative cardiac function.
    The effect of parathyroid hormone(134) on the expressions of type Ⅰ collagen and type Ⅹ collagen in the cartilage endplate on ovariectomized rat model#br#
    LUO Yang， QI Can， LUO Pengyuan, LIANG Shaobo
    2018, 39(2):  155-159.  doi:10.3969/j.issn.10073205.2018.02.008
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    〗［Abstract］ Objective〖HTSS〗〓To investigate the effects of parathyroid hormone（PTH)（134） on the expressions of type Ⅰ collagen and type Ⅹ collagen in the cartilage endplate on  ovariectomized(OVX) rat model.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Thirty female SpragueDawley rats, 3 month of age, were randomly divided into three groups: the shamoperated (Sham) group and two ovariectomized groups treated with vehicle or PTH(134) (30 μg·kg-1·d-1) for twelve weeks. Treatment was started after twelve weeks postOVX and continued for twelve weeks. At the end of experiment, histology and immunohistochemistry analysis were performed to all groups.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓 The cartilage endplate in the Sham group appeared normal. In the OVX group, the cartilage endplate showed degenerative changes, where the bony tissues that contained bone marrow, hematopoietic lineage cells and mineralized bone, became more obvious. In contrast, the histological morphology in the OVX + PTH group showed a fewer bony tissues formed in the cartilage endplate. The results of molecular analysis revealed a significant increase in type Ⅰ collagen and type Ⅹ collagen expressions in the OVX group than that in the Sham group(P＜005), and marked reductions in the type Ⅰ collagen and type Ⅹ collagen expressions in the OVX+PTH group than that in the OVX group(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓PTH(134) treatment was effective in reducing the expression of type Ⅰ collagen and type Ⅹ collagen in the cartilage endplate in OVX rats.
    The clinical research of homemade external fixator in the treatment of multiple metatarsal and phalangeal head fractures#br#
    LIU Yongfeng, ZHANG Ning, LI Shaolian, LI Xinhai, BU Wanying, LIU Zengbing
    2018, 39(2):  160-163.  doi:10.3969/j.issn.10073205.2018.02.009
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    ［Abstract］〓Objective〖HTSS〗〓To investigate the clinical effect of homemade external fixator in the treatment of multiple metatarsal and phalangeal head fractures.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓 A total of 150 cases patient with multiple metatarsal and phalangeal head fractures were selected. They were divided randomly into external fixation group(homemade external fixator fixation) and internal fixation group(conventional open reduction and internal fixation), each with 75 cases. The surgical effect, toe deformity, stump trimming rates and postoperative complications were compared.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓All the patients underwent the operation successfully, and were followed up for 3-12 months. The time of hospitalization and fracture healing in the external fixation group was significantly shorter than that in the internal fixation group, and the cost of treatment was lower than that in the internal fixation group. The difference was statistically significant(P＜005). There were no significant statistical differences in operation time(P＞005). The clinical efficacy for the external fixation group is superior to the internal fixation group, with significantly higher good rate and lower deformity and stump trimming rates. The differences were statistically significant(P＜005). The postoperative complications in the external fixation group is significantly lower than that in the internal fixation group, and the difference was statistically significant(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Homemade external fixator has significant effect and higher safety in the treatment of multiple metatarsal and phalangeal head fractures.
    The application of 3D printing technique in diagnosis and treatment of acetabular fractures and its effect on limb function#br#
    CHENG Huiguang, ZHANG Yumin*, DUAN Ning, MA Tao, LI Zhong
    2018, 39(2):  164-166,170.  doi:10.3969/j.issn.10073205.2018.02.010
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    ［Abstract］ Objective〖HTSS〗〓To study the application of 3D printing technique in diagnosis and treatment of acetabular fractures and its effect on limb function.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 86 patients with acetabular fractures were enrolled in our hospital. According to the order of treatment, 3D group (43 cases, single serial number) was diagnosed and treated by 3D printing techique. The traditional group (43 cases, double serial number) was treated by traditional surgical treatment. Clinical indicators, fracture reduction and hip function recovery were compared in two groups.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The operation time, the intraoperative blood loss and the postoperative drainage volume in the 3D group were significantly less than the traditional group（P＜005）. Excellent rate and the percentage of patients in 3D group were significantly better than the traditional group(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓3D printing technique applying to the diagnosis and treatment of patients with acetabular fractures can shorten the operation time, reduce the intraoperative blood loss and postoperative drainage volume, make the operation more accurate and effectively promote the recovery of postoperative limb function.
    Effect of negative pressure closed drainage in the treatment of complicated infection wound
    LIU Ming， BU Jianli
    2018, 39(2):  167-170.  doi:10.3969/j.issn.10073205.2018.02.011
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    ［Abstract］ Objective〖HTSS〗〓To explore the effect of negative pressure closed drainage (vacuum sealing drainage, VSD) in the treatment of complicated infection wound.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixty patients with complex wound infection were retrospectively studied. The cases were randomly divided into control group and observation group. The control group was used the traditional regular treatment, the observation group was used vacuum sealing drainage. Curative effect, healing time, pain score, and the cost of treatment of wounds in the two groups were compared.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The observation group in the therapeutic effect, healing time, pain score and the cost of treatment of wounds were superior to the control group(P<005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The vacuum sealing drainage treatment of complicated infection wound is curative, the cost of treatment of wounds is low, and it can greatly reduce the pain of patients during treatment and psychological pressure, which is worthy of clinical application.
    Effect of open reduction through lateral minithoracotomy in treating humeral supracondylar fracture and the influence on joint mobility and imaging indexes#br#
    REN Dongwei, YANG Gejun， ZHAO Hualei， ZHA Jianyue， LU Shun， XU Yongsheng
    2018, 39(2):  171-174.  doi:10.3969/j.issn.10073205.2018.02.012
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    ［Abstract］ Objective〖HTSS〗〓To analyze the effect of open reduction through lateral minithoracotomy in the treatment of humeral supracondylar fracture and the influence on joint mobilityand imaging indexes.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and thirty nine cases of patients with humeral supracondylar fracture were  divided into two groups randomly, the observation group(72 cases) was treated with open reduction through lateral minithoracotomy, while the control group(67 cases) was treated with closed reduction. All patients were followedup for 6 months. The clinical efficacy, elbow joint function recovery, joint mobility and radiographic imaging indexes after 3 months of two groups were compared.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The effective rates and the excellent rate of elbow joint function recovery of observation group were significantly better than control group(P＜005). The joint flexion and extension of observation group were significantly higher than control group(P＜005). The carrying angle of observation group was bigger than control group, the Baumann angle and tilting angle of observation group were smaller than control group(P＜005). The adverse rates of observation group was significantly lower than control group(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Open reduction through lateral minithoracotomy can effectively improve the joint mobility and radiographic imaging indexes, promote the recovery of elbow function, which is a good operation method in treating humeral supracondylar fracture.
    Clinical analysis of pelvic floor reconstruction in combined with procedure for prolapse and hemorrhoids in the treatment of Ⅱ and Ⅲ degree rectal prolapse#br#
    WANG Changsheng, CAO Xiufen, ZHANG Yao, YANG Xingze, HE Mei, MA Li, WANG Huijuan
    2018, 39(2):  175-178.  doi:10.3969/j.issn.10073205.2018.02.013
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    ［Abstract］〓Objective〖HTSS〗〓To observe the therapeutic effect of pelvic floor reconstruction in combined with procedure for prolapse and hemorrhoids(PPH) in the treatment of Ⅱ and Ⅲ degree rectal prolapse and the effect on the inflammation and stress reaction.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 208 patients with rectal prolapse Ⅱ  and  Ⅲ  degrees were randomly divided into observation group(104 cases) and control group(104 cases). The patients in the observation group were given pelvic floor reconstruction in combined with PPH, while the patients in the control group were given rectal suspension in combined with anus reduces technique. The effectiveness in the two groups was compared. The postoperative inflammatory cytokines and stress reaction indicators in the two groups were compared in order to evaluate the effects.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The success rate of primary repair in the observation group was significantly higher than that of the control group, the incidence of postoperative complications was significantly lower than that of the control group, the difference was statistically significant(P＜005). The levels of cortisol（COR）, norepinephrine（NE）, prostaglandin E2（PGE2）, interleukin6（IL6）, interleukin10（IL10） and Creactive protein（CRP） in the two groups after treatment were significantly higher than those before treatment(P＜005). There were no significant differences in COR, NE, PGE2, IL6, IL10 and CRP between the two groups(P＞005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The pelvic floor reconstruction in combined with PPH can effectively treat Ⅱ, Ⅲ rectal prolapse in various degrees, reduce the occurrence rate and recurrence rate of postoperative complications. There was no obvious effect on postoperative inflammation and stress response, and has more obvious advantage when compared with Ⅱ, Ⅲ  rectal suspension in combined with anus reduces technique.
    A Metaanalysis about the efficacy of ulinastatin on patients of paraquat poisoning
    LU Xinying1, LI Chaoqian2*
    2018, 39(2):  179-184,188.  doi:10.3969/j.issn.10073205.2018.02.014
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    ［Abstract］ Objective〖HTSS〗〓Owing to the curative effect of ulinastatin to paraquat poisoning is uncertain, we conducted the Metaanalysis about the effection of ulinastatin on patients of paraquat poisoning.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The studies about paraquat poisoning and ulinastatin were searched by the PubMed, Embase, The Cochrane Library, CNKI, VIP and the WANFANG data base，and the studies that are inconsistent with the included standards were deleted. Subsequently, we made the bias risk assessment, included in the Revman 5.3, to assess the evidence of randomized controlled trial(RCT). And the Newcastle Ottawa Scale is used to evaluate the evidence of nonRCT. Afterwards, we calculated the Odd Ratios(OR), standardized mean difference(SMD) and 95% confidence intervals(CI) by random or fixed effects model. And we mapped the forest graphs, Funnel Graphs with the Revman 5.3 software. The evaluation results include the effects between statin group and control group and the mortality rate of acute lung injury/acute respiration distress syndrome(ALI/ARDS), pulmonary fibrosis, respiratory failure, multiple organ dysfunction syndrome(MODS) the incidence rate of change, and inflammatory cytokines interleukin 6(IL6) changes.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓Nine RCT and 6 nonRCT studies were chosen in the meta analysis, which involved 1 133 paraquat poisoning patients. There are 589 patients about ulinastatin group and 544 patients about control group in the meta analysis. And the results of the meta analysis were as followings: the main outcome is mortality/the incidence of inefficiency, and the incidence is less than the control group(OR=0.41，95%CI=0.31~0.55), P＜001). The incidence of MODS is less than control group(OR=0.52， 95%CI=0.37~0.72, P＜001). The change of inflammation cytokine IL6 is more  obvious than control group(SMD=1.32， 95%CI=0.94~1.71, P＜001).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Ulinastatin, which has effective affects in increasing the descent range of  the inflammation cytokine IL6, decreasing the mortality and reducing the incidence of MODS, is more beneficial than the glucocorticoid alone.
    Application of  biomimetic electrical technique in the  patient of symphysis pubis diastasis after spontaneous delivery
    ZHANG Bin
    2018, 39(2):  185-188.  doi:10.3969/j.issn.10073205.2018.02.015
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    ［Abstract］ Objective〖HTSS〗〓To investigate curative effect of biomimetic electrical technique in the  patient of symphysis pubis diastasis after spontaneous delivery.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓This study included 60  patients of symphysis pubis diastasis after spontaneous delivery. The patients were divided randomly into group A(routine nursing group), group B(the pelvis of  external fixation group) and group C(biomimetic electrical technique group). The local pain of  the pelvis and breadth of symphysis pubica were assessed and compared among the 3 groups in 5 days and 6 weeks after spontaneous delivery.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The Visual Analogue Scale(VAS) score was decreased gradually over three groups, the group C  was better than group B and the group B  was better than group A, there were statistically significant differences between groups, time points, and groups· time points in the 3 groups（P＜005）. The 3 groups of pubic symphysis width were shortened with time, the group C was better than group B and the group B was better than group A, there were statistically significant differences between groups, time points, and groups·time points in the 3 groups（P＜005）. 
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Low frequency biomimetic technology is a more effective way to treat pubic symphysis after delivery. It is safe and noninvasive for patients to accept. It can relieve pain and improve quality of life in a short time.
    Effect of ultrasonic curettage and simultaneous tinidazole rinse on the efficacy and gingival crevicular fluid factor in patients with chronic periodontitis
    YANG Jie, WANG Yaozhi, SHEN Xiaoli, AN Xuehui, FAN Mengzhao, KONG Jinming
    2018, 39(2):  189-192.  doi:10.3969/j.issn.10073205.2018.02.016
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    ［Abstract］ Objective〖HTSS〗〓To investigate the effect of ultrasonic curettage and tinidazole flushing on curative effect and gingival crevicular fluid factor level in patients with chronic periodontitis.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and sixty  patients with chronic periodontitis were selected and randomly divided into study group and control group, 80 cases in each group. Study group were treated with ultrasonic scraping synchronous tinidazole, control group scraping were treated with ultrasound scraping cure synchronous distilled water intervention. The plaque index(PLI), periodontal depth(PD), bleeding on probing(BOP) and attachment level(AL) were observed before and 4 weeks after gingival scaling, and the efficacy was evaluated. Gingival crevicular fluid samples were collected before and 4 weeks after gingival scaling, Enzyme linked immunosorbent assay was used to detect interleukin 8(IL8), matrix metalloproteinase 8(MMP8) and tissue inhibitor of matrix metalloproteinase 1( TIMP1) level.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓After curettage, the PLI, PD, BOP and AL in the study group were lower than those before the treatment and the control group, the total effective rate was better than the control group(P＜005). The level of IL8, MMP8 and TIMP1 in the study group was lower than that before the treatment and the control group(P＜005).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Ultrasonic subgingival scaling and synchronous tinidazole flushing can significantly reduce the levels of IL8, MMP8 and TIMP1 in gingival crevicular fluid factor in patients with chronic periodontitis and effectively relieve the inflammatory reaction, with significant clinical effect and clinical value.
    Application of SWE quantitative analysis to evaluate the pathologic response in breast cancer after adjuvant chemotherapy and its correlation with tumor hemoglobin
    TANG Zhiyong， JIN Zhongmin， ZHU Guangqing
    2018, 39(2):  193-197.  doi:10.3969/j.issn.10073205.2018.02.017
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    ［Abstract］ Objective〖HTSS〗〓To explore the application of shearwave elastography(SWE) quantitative analysis to evaluate the pathologic response in breast cancer after adjuvant chemotherapy and its correlation with tumor hemoglobin.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 56 patients with breast cancer(56 lesions) were treated with neoadjuvant chemotherapy(NAC) and surgery after biopsy diagnosis. The maximal modulus of elasticity was measured by SWE before and after NAC chemotherapy, the total hemoglobin concentration(HbT) was measured by USdiffuse optical tomography(USDOT). The pathological evaluation was chosen as gold standard. The efficacy of NAC evaluation by the RECIST1.1 and the maximum elastic modulus was compared, and the correlation between HbT and HbT was analyzed.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The reduction rate of tumor diameter, HbT value and maximum elastic modulus in significant pathological response patients were significant different with nonsignificant pathological response patients（P＜005）. The sensitivity, specificity, accuracy and Kappa values of NAC evaluation by RECIST1.1 were 86.4%, 91.7%, 87.5% and 0.678, and the sensitivity, specificity, accuracy and Kappa values of NAC evaluation by maximal modulus of elasticity were 88.6%, 75.0%, 85.7% and 0.600, there was no difference in two groups（P＞005）. There was a significant positive correlation between the maximum elastic modulus reduction rate and the HbT reduction rate(r=0.785, P=0.000).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The maximal modulus of elasticity of breast lesions measured by SWE can reflect tumor hemoglobin level objectively, wihch can be convenient, effective and accurate to evaluate NAC effacy with reduction rate of maximum elastic modulus.
    Study on the clinical effect of the application of dental implant combined with orthodontic in the treatment of congenital missing teeth#br#
    YU Aixia
    2018, 39(2):  198-200,205.  doi:10.3969/j.issn.10073205.2018.02.018
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    ［Abstract］ Objective〖HTSS〗〓To explore the clinical effect of the application of dental implant combined with orthodontic in the treatment of congenital missing teeth.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and thirty cases of patients with congenital missing teeth were chosen randomly.According to the digital table method, all patients were divided into control group and observation group. The patients in the control group were treated with dental implant treatment alone, while the patients in the observation group received dental implant combined with orthodontic treatment. Planting success rate, bite force, chewing function and language function recovery after treatment were compared and analyzed between two groups.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓The planting success rates at 3, 6 months and 1 years after dental implant treatment in the observation group were significantly higher than that in the control group(P<0.05).The bite force after treatment in the observation group was significantly larger than that in the control group(P<0.05).The chewing function and score of language function after treatment in the observation group were significantly higher than that in the control group(P<0.05).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Dental implant combined with orthodontic in the treatment of patients with congenital missing teeth has a significant effect,which can improve the success rate of dental implant,promote the restoration of tooth bite force and improve the chewing function and language function of the patients.It has great clinical significance.
    Study on T lymphocyte subsets and viral replication and viral load in children with hepatitis B
    ZHANG Junting, AN Hebing
    2018, 39(2):  201-205.  doi:10.3969/j.issn.10073205.2018.02.019
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    ［Abstract］〓Objective〖HTSS〗〓To explore the correlation of T lymphocytes with virus replication and viral load in children with hepatitis B.
    〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Fiftyeight children with chronic hepatitis B, who were positive for hepatitis B virusdesoxyribose nucleic acid(HBVDNA), were selected as the research subjects. Among them, 41 had positive human hepatitis B virus e antigen（HBeAg）, 17 had negative HBeAg, 24 had low viral load, 19 had moderate viral load, and 15 had high viral load. Moreover, 35 healthy children were served as the control group. FQPCR was used to detect HBVDNA. FCM was used to detect CD3+, CD4+, and CD8+. CD4+/CD8+ were calculated.
    〖HTH〗〖WTHZ〗Results〖HTSS〗〓CD3+, CD4+, CD4+/CD8+ in children with Chronic hepatitis B were lower than the control group, CD8+ was higher than the control group (P＜001). CD3+, CD4+, CD4+/CD8+ in load group were lower than that of low load group,  CD3+, CD4+, CD4+/CD8+in higher load group were lower than that of low load group and load group(P＜001), load group and high load of CD8+ was higher than that of low load group(P＜001). The CD3+, CD4+ and CD4+/CD8+ of HBeAg positive children were lower than those of HBeAg negative children, and CD8+ was higher than that of HBeAg negative children(P＜001).
    〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Changes of T lymphocyte subsets in children with hepatitis B was not only associated with HBV infection, but also correlated with the replication of HBVDNA, which can further aggravate the cellular immune dysfunction.