25羟维生素D3、hsCRP与糖尿病视网膜病变相关性研究

doi:10.3969/j.issn.10073205.2018.10.008

摘要/Abstract

摘要：

［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗通过测定2型糖尿病合并视网膜病变患者血清25羟维生素D3和超敏C反应蛋白(highsensitivity Creactive protein，hsCRP )水平，探讨25羟维生素D3、hsCRP与糖尿病视网膜病变（diabetic retinopathy,DR）的关系。
〖HTH〗方法〖HTSS〗〖KG*2〗选择2型糖尿病患者560例，根据眼底照相或眼底造影分为2型糖尿病不伴视网膜病变组(NDR组，230例)，2型糖尿病伴背景期视网膜病变组(BDR组，190例)，2型糖尿病伴增殖期视网膜病变组（PDR组，140例）。选取同期体检的健康人140例作为对照组。收集所有研究对象临床资料，检测其血清25羟维生素D3、hsCRP水平。

〖HTH〗结果〖HTSS〗〖KG*2〗4组间年龄、体重指数(body mass index,BMI)、总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、低密度脂蛋白胆固醇(lowdensity lipoproteincholesterol,LDLC)、高密度脂蛋白胆固醇(highdensity lipoproteincholesterol,HDLC)差异均无统计学意义(P>0.05)；NDR组、BDR组、PDR组病程、空腹血糖（fasting blood glucose，FBG）、糖化血红蛋白(hemoglobin A1c,HbA1c)、hsCRP、25羟维生素D3与对照组差异均有统计学意义(P＜005)；BDR组、PDR组病程、FBG、HbA1c、hsCRP、25羟维生素D3与NDR组差异均有统计学意义(P＜005)；BDR组病程、FBG、HbA1c、hsCRP、25羟维生素D3与PDR组差异均有统计学意义(P＜005)。Pearson相关分析显示，病程、FBG、HbA1c、hsCRP与DR呈正相关(P＜005)，25羟维生素D3与DR呈负相关(P＜005)。Logistic回归分析显示，病程、FBG、HbA1c、hsCRP是DR发病的独立危险因素(P＜005)。
〖HTH〗结论〖HTSS〗〖KG*2〗DR患者血清25羟维生素D3明显减低，hsCRP明显升高，与视网膜病变严重程度相关。维生素D缺乏可能通过hsCRP导致DR发生发展。

关键词: 糖尿病视网膜病变, 骨化二醇, C反应蛋白质

Abstract: ［Abstract］ Objective〖HTSS〗〓To test the level of serum 25hydroxy vitamin D3 and highsensitivity Creactive protein(hsCRP ) in type 2 diabetic patients with retinopathy, and to investigate the relationship between 25hydroxy vitamin D3, hsCRP and type 2 diabetic retinopathy.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 560 cases with type 2 diabetes were selected, including type 2 diabetes mellitus without retinopathy(NDR, n=230), type 2 diabetes with background retinopathy(BDR, n=190), type 2 diabetes with proliferative retinopathy(PDR, n=140), 140 healthy subjects were selected as control group at the same time. All clinical data were collected, serum levels of 25hydroxy vitamin D3 and hsCRP were determined.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There was no significant difference in age, body mass index(BMI), total cholesterol(TC), triglyceride(TG), lowdensity lipoproteincholesterol(LDLC) and highdensity lipoproteincholesterol(HDLC) in the four groups(P＞005). The duration of disease, fasting blood glucose(FBG), hemoglobin A1c(HbA1c), hsCRP and 25 hydroxy vitamin D3 in the group of NDR, BDR and PDR were significantly different from those of the control group(P＜005). The duration of disease, FBG, HbA1c, hsCRP, 25hydroxy vitamin D3 of the group BDR and PDR had significant difference compared to the group NDR(P＜005). The duration of disease, FBG, HbA1c, hsCRP, 25hydroxy vitamin D3 in the group BDR were significantly different from those in the group PDR(P＜005). After pearson correlation analysis, the duration of disease, FBG, HbA1c, and hsCRP were positively correlated with DR(P＜005), and 25hydroxy vitamin D3 was negatively correlated with DR(P＜001). After logistic regression analysis, the duration of disease, FBG, HbA1c, and hsCRP were independent risk factors of DR, and 25hydroxy vitamin D3 was the protective factor of DR(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The serum 25hydroxy vitamin D3 levels in patients with type 2 diabetic retinopathy were significantly decreased, hsCRP was significantly increased. They were associated with the severity of retinopathy. Vitamin D deficiency may lead to the development of diabetic retinopathy through hsCRP.

Key words: diabetic retinopathy, calcifediol, Creactive protein

王霖霞，苏〓娜，张云娜，郭宁宁，王光亚. 25羟维生素D3、hsCRP与糖尿病视网膜病变相关性研究[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2018.10.008.

WANG Linxia, SU Na, ZHANG Yunna, GUO Ningning, WANG Guangya.

Study on the relationship between 25hydroxy vitamin D3， hsCRP and type 2 diabetic retinopathy

[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2018.10.008.

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