主动脉夹层合并急性肺损伤与血清CRP、MCP-1、MMP9的相关性

doi:10.3969/j.issn.1007-3205.2020.10.003

河北医科大学学报 ›› 2020, Vol. 41 ›› Issue (10): 1126-1129.doi: 10.3969/j.issn.1007-3205.2020.10.003

主动脉夹层合并急性肺损伤与血清CRP、MCP-1、MMP9的相关性

1.河北省邯郸市中心医院心血管外科，河北邯郸 056000；2.河北省邯郸市第一医院呼吸科，河北邯郸 056000

出版日期:2020-10-25 发布日期:2020-10-27
作者简介:刘健（1979-），男，河北邯郸人，河北省邯郸市中心医院副主任医师，医学学士，从事心血管外科疾病诊治研究。
基金资助:
河北省医学科学研究课题计划（20200474）

The correlations between acute lung injury of aortic dissection with serum CRP, MCP-1, and MMP-9

1. Department of Cardiovascular Surgery, Handan Central Hospital of Hebei Province, Hebei Province,
Handan 056000,China; 2.Department of Respiration, Handan First Hospital of Hebei Province,
Hebei Province, Handan 056000, China

Online:2020-10-25 Published:2020-10-27

摘要/Abstract

摘要： 目的探讨主动脉夹层（aortic dissection,AD）合并急性肺损伤（acute lung injury,ALI）与血清C反应蛋白（C-reactiveprotein,CRP）、单核细胞趋化蛋白1（monocyte chemotactic protein 1,MCP-1）、基质金属蛋白酶9（matrix metallprotenaine 9,MMP9）的相关性。
方法选取AD患者92例进行研究，其中发生ALI患者42例（ALI组），无发生ALI患者50例（非ALI组），选取同期体检健康者50例（对照组），通过酶联免疫吸附法（enzyme-linked immunosorbent assay,ELISA）检测所有受试者血清CRP、MCP-1、MMP9水平，3者表达相关性及对ALI预测价值。
结果非ALI组和ALI组血清CRP、MCP-1、MMP9水平均高于对照组，ALI组高于非ALI组，差异均有统计学意义（P＜0.05）。非ALI组和ALI组血清白细胞介素6（interleukin- 6,IL-6）、、肿瘤坏死因子α（tumor necrosis factor-α，TNF-α）水平均高于对照组，ALI组均高于非ALI组；非ALI组和ALI组血清IL-10均低于对照组，且ALI组低于非ALI组，差异均有统计学意义（P＜0.05）。通过Pearson相关性分析显示，ALI组血清CRP与MCP-1、MMP9呈正相关性（r=0.827，P＜0.001；r=0.868，P＜0.001），MCP-1与MMP9呈正相关性（r=0.741，P＜0.001）。 CRP的AUC为0.856，诊断敏感度为66.70%，特异度为88.00%，MCP-1的AUC为0.769，诊断敏感度为69.00%，特异度为76.00%，MMP9的AUC为0.884，诊断敏感度为81.00%，特异度为90.00%，三者联合检测的AUC为0.930，诊断敏感度为83.30%，特异度为90.00%。
结论 AD合并ALI患者血清CRP、MCP-1、MMP9水平升高，3者呈正相关性，CRP、MCP-1、MMP9联合诊断敏感度、特异度高，对AD合并ALI具有较高诊断价值。

关键词: 主动脉疾病, 急性肺损伤, C反应蛋白质

Abstract:

Objective To investigate the correlations between acute lung injury(ALI) in aortic dissection(AD) with serum C-reactive protein(CRP), monocyte chemoattractant protein-1(MCP-1), matrix metalloproteinase-9(MMP9).

Methods A total of 92 aortic dissection patients were selected for the study, among them, 42 were ALI patients(ALI group), and 50 were non-ALI patients(non-ALI group), 50 healthy persons(control group) were selected for physical examination during the same period, the levels of serum CRP, MCP-1, and MMP-9 were detected by enzyme-linked immunosorbent assay（ELISA）, the correlations of the expressions of CRP, MCP-1, and MMP-9 and their predictive values for ALI were also studied.
Results The levels of serum CRP, MCP-1 and MMP9 in non ALI group and ALI group were higher than those in control group, and those in ALI group were higher than those in non ALI group(P＜0.05). The levels of serum interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） in non ALI group and ALI group were higher than those in control group, and those in ALI group were higher than those in non ALI group; Serum IL-10 in non ALI group and ALI group was lower than that in control group, and the difference was statistically significant(P＜0.05). Pearson correlation analysis showed that serum CRP was positively correlated with MCP-1 and MMP9(r=0.827, P＜0.001; r=0.868, P＜0.001), and MCP-1 was positively correlated with MMP9(r=0.741, P＜0.001). The AUC of CRP was 0.856, the diagnostic sensitivity was 66.70%, the specificity was 88.00%, the AUC of MCP-1 was 0.769, the diagnostic sensitivity was 69.00%, the specificity was 76.00%, the AUC of MMP9 was 0.884, the diagnostic sensitivity was 81.00%, the specificity was 90.00%. The AUC of combined detection of CRP and MCP-1 was 0.930, the diagnostic sensitivity was 83.30%, and the specificity was 90.00%.
Conclusion The levels of CRP, MCP-1, and MMP9 in serum of patients with acute lung injury caused by aortic dissection are increased, and they are positively correlated, the combined diagnosis of CRP, MCP-1, and MMP9 has high sensitivity and specificity, it has high diagnostic value for acute lung injury caused by aortic dissection.

Key words: aortic diseases, acute lung injury, C reactive protein

刘健, 宋然, 宋朝国, 张健. 主动脉夹层合并急性肺损伤与血清CRP、MCP-1、MMP9的相关性[J]. 河北医科大学学报, 2020, 41(10): 1126-1129.

LIU Jian, SONG Ran, SONG Zhao-guo, ZHANG Jian. The correlations between acute lung injury of aortic dissection with serum CRP, MCP-1, and MMP-9[J]. Journal of Hebei Medical University, 2020, 41(10): 1126-1129.

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主动脉夹层合并急性肺损伤与血清CRP、MCP-1、MMP9的相关性

The correlations between acute lung injury of aortic dissection with serum CRP, MCP-1, and MMP-9

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