河北医科大学学报

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中性粒细胞/淋巴细胞比值——预测上尿路结石经皮肾镜术后全身炎症反应综合征的新指标

  

  1. 中国人民解放军第二五二医院泌尿外科,河北 保定 071000
  • 出版日期:2018-12-25 发布日期:2018-11-30
  • 作者简介:史建国(1974-),男,河北保定人,中国人民解放军第二五二医院副主任医师,医学博士,从事泌尿外科疾病诊治研究。
  • 基金资助:
    保定市科技计划项目(17ZF228)

Neutrophil/lymphocyte ratio: a new indicator for predicting systemic inflammatory response syndrome after percutaneous nephrolithotomy for upper urinary tract calculi#br#

  1. Department of Urology, 252nd Hospital of PLA, Hebei Province, Baoding 071000, China
  • Online:2018-12-25 Published:2018-11-30

摘要: [摘要]〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨上尿路结石经皮肾镜碎石术后全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)的危险因素,评估术前中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)在预测术后SIRS中的作用。
〖HTH〗方法〖HTSS〗〖KG*2〗经皮肾镜取石术后患者323例,收集其术前术中资料,根据术后是否出现SIRS分为SIRS组和非SIRS组,比较2组糖尿病史、感染性结石、多通道手术、术前尿培养阳性率、NLR、血红蛋白含量、白蛋白含量、结石负荷和手术时间。
〖HTH〗结果〖HTSS〗〖KG*2〗323例患者中,48例术后出现SIRS。SIRS组糖尿病史、感染结石史、围手术期输血史发生率均高于非SIRS组,SIRS组结石负荷、NLR高于非SIRS组,差异有统计学意义(P<005)。Logistic 回归分析显示NLR(OR=8.886,P=0000)、感染性结石(OR=6.742, P=0000)为经皮肾镜术后SIRS发生的独立危险因素。ROC曲线图分析显示术前NLR最佳截断点为2.31,其敏感度为72.9%,特异度为75.6%,曲线下面积为80.8%。
〖HTH〗结论〖HTSS〗〖KG*2〗术前NLR水平可用于预测经皮肾镜术后SIRS的发生,其具有简便易于测量的特点,且其费用低廉,是预测术后感染的一个良好指标。

关键词: 全身炎症反应综合征, 尿路结石, 危险因素

Abstract: 〗[Abstract] Objective〖HTSS〗〓To evaluate the risk factors of systemic inflammatory response syndrome(SIRS) after percutaneous nephrolithotomy for upper urinary calculi, and to evaluate the role of neutrophils/lymphocyte ratio in prediction of postoperative SIRS.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Three hundred and twentythree patients after percutaneous nephrolithotomy were divided into SIRS group and nonSIRS group according to whether SIRS occurred or not. The diabetes history, infectious stones, multichannel operation, positive rate of preoperative urine culture, NLR, hemoglobin content, albumin content, stone load and operation time were compared between the two groups. 
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Among 323 patients, 48 had SIRS after operation. The incidence of diabetes history, infection stone history and perioperative blood transfusion history in SIRS group were higher than those in nonSIRS group. The stone load and NLR in SIRS group were higher than those in nonSIRS group(P<005). Logistic regression showed that NLR(OR=8.886, P=0000) and infectious stones(OR=6.742, P=0000) were independent risk factors for SIRS after percutaneous nephroscopy. ROC curve analysis showed that the best cutoff point of NLR before operation was 2.31, the sensitivity was 72.9%, the specificity was 75.6%, and the area under curve was 80.8%.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Preoperative NLR level can be used to predict the occurrence of SIRS after percutaneous nephrolithotomy. This index is simple and easy to measure, and its cost is low. It is a good index for predicting postoperative infection.

Key words: systemic inflammatory response syndrome, urinary calculi, risk factors