关键词: 子宫内膜肿瘤, 三氧化二砷, 大鼠

Abstract: Objective To explore the inhibitory effect of arsenic troixide(AS2 O 3 )on the growth of nude mice bearing human endometrial carcinoma transplanted subcutaneously and its mechanisms.Methods Human endometrial cancer xenograft models were established in nude mice using HEC-1-A cell,then were divided into five groups as following,group A(AS2 O 3 4mg· kg-1 ·d-1 ),group B(AS2 O3 6mg· kg-1 · d-1 ),group C(AS2 O 3 8mg· kg-1 · d-1 ),group D (cisplatin 3mg·kg-1 ·d-1 ),and group E(saline group).The drugs were given intraperitoneally for 14 d,then the inhibition rate of tumor volume and tumor mass were calculated.The change of body mass of nude mice after treatment was measured.Results The tumor volume was inhibited by 50.97%,75.58%,56.92%,52.23%,and the tumor mass was inhibited by 10.15%,29.33%, 16.67%,14.69%,respectively,in group A,group B,group C,group D,as compared with the saline group,the difference were statistically significant,respectively (P <0.05).AS2 O 3 had no effect on body mass,while the change of nude mice body mass was significant after treatment in group D. Conclusion AS2 O3 could inhibit the growth of human endometrial cancer xenograft in nude mice. Furthermore,AS2 O3 has stronger inhibitive effect than clisplatin,with lighter side effect.Thus, AS2 O3 is a new drug for endometrial cancer treatment.

Key words: endometrial neoplasms:arsenic trioxide, rats