河北医科大学学报 ›› 2024, Vol. 45 ›› Issue (6): 724-728.doi: 10.3969/j.issn.1007-3205.2024.06.017

• • 上一篇    下一篇

中老年住院患者同型半胱氨酸与内脏脂肪型肥胖的相关性研究

  

  1. 1.首都医科大学宣武医院老年医学科，北京 100053；2.首都医科大学宣武医院老年医学科，国家老年疾病临床医学研究中心，北京 100053

  • 出版日期:2024-06-25 发布日期:2024-06-25
  • 作者简介:李碧汐(1990-)，女，北京人，首都医科大学宣武医院主治医师，医学博士，从事老年疾病诊治研究。
  • 基金资助:
    国家重点研发计划项目(2020YFC2008604)

Correlation between homocysteine and visceral fat obesity in middle-aged and elderly inpatients

  1. 1.Department of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China; 
    2.Department of Geriatrics, Xuanwu Hospital of Capital Medical University/National 
    Clinical Research Center for Geriatric Disease, Beijing 100053, China

  • Online:2024-06-25 Published:2024-06-25

HTML

PDF (PC)

36

摘要： 目的 探讨同型半胱氨酸（homocysteine,Hcy）对中老年住院患者内脏脂肪型肥胖的影响。
 方法 连续入选宣武医院老年医学科患者354例，采集临床和实验室资料、估算内脏脂肪面积（estimated visceral fat area,eVFA），根据是否合并内脏脂肪型肥胖（visceral fat obesity,VFO）分为VFO组（252例）和非VFO组（102例），采取横断面研究Hcy对中老年住院患者VFO的影响。
 结果 与非VFO组比较，VFO组的体重指数、Hcy等指标均明显高于非VFO组（P＜0.05）。二分类Logistic回归分析显示性别、BMI、Hcy是VFO的危险因素(P＜0.05)。Spearman相关性分析显示，Hcy与eVFA呈正相关(r=0.255, P＜0.001)，调整年龄后仍相关。按照体重指数分层观察Hcy与体重正常组(r=0.356，P=0.001)和超重组(r=0.255，P＜0.001)的eVFA均呈正相关，调整年龄后仍相关。ROC曲线得出截断值为11.05，敏感度为86%，特异度为42%(ROC曲线下面积=0.646,95%CI:0.572~0.719,P＜0.001)。
 结论 中老年住院患者Hcy与eVFA具有相关性，Hcy为VFO的危险因素，中老年住院患者应该更为严格地控制Hcy水平。


关键词: 肥胖, 腹部, 同型半胱氨酸, 内脏脂肪面积

Abstract: Objective To investigate the effect of homocysteine (Hcy) on visceral fat obesity (VFO) in middle-aged and elderly inpatients. 
Methods In total, 354 patients admitted to Department of Geriatrics, Xuanwu Hospital were consecutively selected. The clinical and laboratory examination data, and estimated visceral fat area (eVFA) were collected. The patients were divided into VFO group (n=252) and non-VFO group (n=102) according to presence of combined VFO. The effects of Hcy on VFO in middle-aged and elderly inpatients were investigated by cross-sectional study. 
Results Body mass index (BMI) and Hcy were significantly higher in VFO group than in non-VFO group (P＜0.05). Binary Logistic regression analysis showed that gender, BMI and Hcy were risk factors for VFO (P＜0.05). Spearman correlation analysis showed that Hcy was positively correlated with eVFA (r=0.255, P＜0.001) and there was still a correlation after adjusting for age. Stratified by BMI, Hcy was positively correlated with eVFA in the normal weight group (r=0.356, P=0.001) and overweight group (r=0.255, P＜0.001), even after adjusting for age. Receiver operating characteristic (ROC) curve analysis displayed that the cut-off value of Hcy was 11.05, with a sensitivity of 86%, and a specificity of 42% ［the area under the ROC curve (AUC)=0.646, 95%CI: 0.572-0.719, P＜0.001］. 
Conclusion Hcy is positively related with eVFA, and Hcy is a risk factor for VFO. Therefore, Hcy levels should be more tightly controlled in middle-aged and elderly inpatients. 


Key words: obesity, abdominal, homocysteine, visceral fat area

版权所有 © 《河北医科大学学报》编辑部
本系统由北京玛格泰克科技发展有限公司设计开发