关键词: 多囊卵巢综合征, 白细胞介素10, 多态性, 单核苷酸

Abstract: Objective To explore interleukin-10 (IL-10) gene rs1800871 A/G single nucleotide polymorphism (SNP) and rs1800872 T/G SNP  and genetic susceptibility to polycystic ovary syndrome (PCOS). 
Methods The SNP of IL-10 gene rs1800871 A/G and rs1800872 T/G were analyzed by SNaPshot SNP typing method in 121 PCOS patients and 158 healthy controls. 
Results The level of body mass index, family history of obesity and T level in case group were higher than those in control group, while FSH level was lower than that in healthy control group (P＜0.05). Polymorphic loci of Rs1800871 A/G SNP and rs1800872 T/G SNP of IL-10 were analysed by using SHEsis software, and results showed that complete linkage exists between these two SNPs (D＇=1). There were significant differences in genotype composition and alleles between the case group and the healthy control group (P＜0.05). Logistic regression analysis showed that family history of obesity and rs1800871A/G SNPof IL-10 gene were risk factors for PCOS (P＜0.05). 
Conclusion The IL-10 rs1800871 A/G increases genetic susceptibility to PCOS, and carrying AG and GG genotypes may increase the risk of PCOS. 

Key words: polycystic ovary syndrome, interleukin-10, polymorphism, single nucleotide