河北医科大学学报 ›› 2021, Vol. 42 ›› Issue (2): 177-180,191.doi: 10.3969/j.issn.1007-3205.2021.02.012

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急性淋巴细胞白血病患儿血清铁调素水平及临床意义

  

  1. 河北医科大学第二医院儿科，河北 石家庄 050000
  • 出版日期:2021-02-25 发布日期:2021-03-09
  • 作者简介:刘娜 （1982-），女，河北藁城人，河北医科大学第二医院副主任医师，医学硕士，从事血液肿瘤疾病诊治研究。
  • 基金资助:
    河北省医学科学研究课题计划（20200894）

Serum Hepcidin levels and their clinical significance in children with acute lymphoblastic leukemia

  1. Department of Pediatrics, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Online:2021-02-25 Published:2021-03-09

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摘要： 目的  探索急性淋巴细胞白血病（acute lymphoblastic leukemia，ALL）患儿血清铁调素（Hepcidin）水平及其临床意义。
方法  选择ALL患儿30例为研究对象，随访时间截止到2020年2月，应用酶联免疫吸附试验（enzyme-linked immunosorbent assay，ELISA）检测患者Hepcidin、促红细胞生成素（erythropoietin，EPO）水平，应用血液分析仪检测研究对象血红蛋白（hemoglobin，HGB）水平，应用特种蛋白免疫分析仪检测研究对象铁蛋白（Ferritin）、转铁蛋白水平(Transferrin)，C反应蛋白（C-reactive protein，CRP）水平，并分析ALL患儿Hepcidin水平与预后的关系，以及Hepcidin与EPO、HGB、Ferritin、Transferrin的相关关系。
结果  ①30例ALL患者按Hepcidin表达水平分成2组，高水平组Hepcidin表达量为（114.4±48.63） μg/L，低水平组为（21.98±15.94） μg/L，组间比较差异有统计学意义（P＜0.001）。②30例ALL患者5年总体EFS为77.586%。Hepcidin高水平和低水平2组生存曲线比较差异无统计学意义（P＞0.05），单因素和多因素分析Hepcidin水平都不是影响ALL患者预后的危险因素。③Hepcidin与Ferritin浓度呈正相关关系（r=0.466,P=0.010），Hepcidin水平与HGB含量呈负相关关系（r=-0.407，P=0.026）。
结论  ①ALL 患儿血清铁调素水平不是影响预后的独立因素。② ALL患儿铁调素的表达与血红蛋白水平呈负相关，与铁蛋白水平呈正相关，铁代谢异常可能是引起儿童ALL贫血的原因。


关键词: 白血病,B细胞, 铁调素, 预后

Abstract: Objective  To investigate the serum levels of Hepcidin and their clinical significance in children with acute lymphoblastic leukemia(ALL). 
Methods  A total of 30 children with ALL were selected as the study subjects. They were followed up up to February 2020. Serum Hepcidinlevels and erythropoietin(EPO) were detected by enzyme-linked immunosorbent assay(ELISA).The blood analyzer was used to detect the hemoglobin(HGB) level of the subjects, and the Ferritin, Transferrin and C-reactive protein(CRP) levels of the subjects were detected by the special protein immunoanalyzer.The relationship between the Hepcidin level and the prognosis of ALL children was analyzed, as well as the correlation of Hepcidin with EPO, HGB, Ferritin and Transferrin. 
Results  ①All 30 patients with ALL were divided into two groups according to the expression level of Hepcidin. The expression level of Hepcidin was(114.4±48.63) μg/L in the high Hepcidin level group and(21.98±15.94) μg/L in the low Hepcidin level group, with significant difference(P＜0.001). ②The total 5-year EFS of 30 ALL patients was 77.586%. There was no statistically significant difference in survival curves between the high and low Hepcidin level groups(P＞0.05). ③There was a positive correlation between Hepcidin and Ferritin concentration(r=0.466， P=0.010). There was a negative correlation betweenHepcidin level and HGB content(r=-0.407， P=0.026). 
Conclusion  ①Serum Hepcidin level in ALL children is not an independent factor affecting prognosis. ②The expression of Hepcidin in children with ALL is negatively correlated with the hemoglobin content, and positively correlated with the Ferritin concentration. Abnormal iron metabolism may be the cause of anemia in children with ALL.


Key words: leukemia, B-cell, hepcidin, prognosis

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