支气管哮喘患者外周血CD4+T、CD8+T、Th17、IL17表达水平与肺功能的相关性研究

doi:10.3969/j.issn.10073205.2018.05.003

摘要/Abstract

摘要： ［摘要］〓
〖HTH〗目的〖HTSS〗〖KG*2〗探讨支气管哮喘患者体内炎性细胞和炎性因子（CD4+T、CD8+T、Th17、IL17）表达水平与肺功能的相关性。
〖HTH〗方法〖HTSS〗〖KG*2〗收集268例支气管哮喘患者，其中间歇-轻度142例，中重度126例，同时以60例健康体检者作为对照组。①测定所有入组者血液酸碱度(pH)、动脉血氧分压(arterial oxygen partial pressure，PaO2)、动脉血氧饱和度(arterial oxygen saturation，SaO2)和动脉血二氧化碳分压(arterial carbon dioxide pressure，PaCO2)；②测定所有入组者肺活量(vital capacity，VC)，1秒钟用力呼气容积与预计值的百分比(FEV1/Pre%)及呼气流量峰值(peak expiratory flow，PEF)；③检测所有入组者外周血CD4+T、CD8+T、Th17、IL17的表达水平；④探讨患者CD4+T、CD8+T、Th17、IL17表达水平与肺功能的相关性。
〖HTH〗结果〖HTSS〗〖KG*2〗①中重度组和间歇-轻度组PaCO2较健康对照组明显偏高(P＜005)；中重度组与间歇-轻度组相比，pH值、PaO2、SaO2均明显偏低(P＜005)。②与健康对照组相比，间歇-轻度组和中重度组肺功能指标明显偏低（P＜005）；中重度组与间歇-轻度组比较，肺功能指标显著降低(P＜005)。③间歇-轻度组和中重度组Th17、CD8+T、IL17水平显著高于健康对照组，CD4+T明显低于健康对照组(P＜005)；中重度组Th17、CD8+T、IL17水平高于间歇-轻度组，CD4+T细胞水平低于间歇-轻度组(P＜005)。④哮喘患者体内CD4+T细胞水平与VC、FEV1/Pre及PEF均呈正相关；Th17、CD8+T、IL17水平与VC、FEV1/Pre及PEF均呈负相关。⑤中重度组与间歇-轻度组相比，CD4+T、CD8+T、Th17细胞及炎性因子IL17水平与肺功能的相关性更高。
〖HTH〗结论〖HTSS〗〖KG*2〗CD4+T、CD8+T、Th17和IL17表达水平可作为支气管哮喘病情变化的判断指标，临床诊治中应结合患者机体内环境的变化情况，制定科学合理的治疗方案。

关键词: 哮喘, 呼吸功能试验, 血气分析

Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the correlation between the level of inflammatory cells, inflammatory factors(CD4+T, CD8+T, Thl7, IL17) and pulmonary functions of patients with bronchial asthma.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Two hundred and sixtyeight patients with bronchial asthma were enrolled in this study. One hundred and fortytwo cases of moderate intermittentmild, 126 cases of moderate to severe and 60 cases of healthy subjects were collected as control group. ①The blood pH (pH), arterial oxygen partial pressure(PaO2), arterial oxygen saturation(SaO2), and arterial carbon dioxide pressure(PaCO2) were measured. ②The vital capacity (VC), the forced expiratory volume in one second/predicted value%(FEV1/Pre%) and peak expiratory flow(PEF) were measured for all participants. ③The levels of CD4+T, CD8+T, Thl7, IL17 in peripheral blood were detected. ④Correlation between the expression of CD4+T, CD8+T, Th17, IL17 and pulmonary functions were explored.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓①The PaCO2 value of the moderate to severe group and the intermittentmild group were significantly higher than that of the healthy control group(P＜005). The pH, PaO2 and SaO2 were significantly lower in the moderate to severe group than those in the intermittentmild group(P＜005). ②Compared with the control group, the pulmonary function indexes of the patients in the intermittentmild group and the moderate to severe group were significantly lower than those in the control group(P＜005). The pulmonary function indexes were significantly lower in the moderate to severe group than those in the intermittentmild group(P＜005). ③The levels of Th17, CD8+T, IL17 in the intermittentmild group and the moderate to severe group were significantly higher than those in control group. CD4+T cells were lower than those in control group. The levels of Th17, CD8+T, IL17 in the moderate to severe group were significantly higher than those in intermittentmild group, CD4+T cells were lower than those in the intermittentmild group(P＜005). ④CD4+T cell level was positively correlated with VC, FEV1/Pre and PEF in asthmatic patients. Th17, CD8+T and IL17 levels were negatively correlated with VC, FEV1/Pre% and PEF. ⑤The correlation between CD4+T, CD8+T, Th17, IL17 levels and pulmonary functions in the moderate and severe group were higher than those in the intermittentmild group.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The expression levels of CD4+T, CD8+T, Th17 and IL17 could be used as indicators for the in vivo changes of bronchial asthma. In the clinical diagnosis and treatment, we should give a scientific and reasonable treatment plan combined with the changes of the in vivo environment of the patients.

Key words: asthma, pulmonary function test, blood gas analysis

李小明. 支气管哮喘患者外周血CD4+T、CD8+T、Th17、IL17表达水平与肺功能的相关性研究[J]. 河北医科大学学报, doi: 10.3969/j.issn.10073205.2018.05.003.

LI Xiaoming. Correlation between expression levels of CD4+T, CD8+T, Th17, IL17 and pulmonary functions in peripheral blood of patients with bronchial asthma#br#[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2018.05.003.

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[9]	潘文森1，肖冉冉1，关继涛2，李爱民3，杨红申1. 阿托伐他汀对哮喘大鼠气道炎症、重塑及血清学相关炎症指标的影响[J]. 河北医科大学学报, 2017, 37(9): 1007-1010,1019.
[10]	施雄飞，邵成喜，杨秋宝，罗坤锋. 急诊应用布地奈德联合福莫特罗干粉剂治疗支气管哮喘的效果观察[J]. 河北医科大学学报, 2017, 37(8): 953-956.
[11]	李晓光1，安小军2，韩〓玮3，史翠红3，王建平4，刘艳清5. 利美达松对哮喘持续状态的临床疗效及对呼气流速峰的影响[J]. 河北医科大学学报, 2017, 37(5): 595-598.
[12]	李国华1，周希胜2，李亚芳（通讯作者）3. 抗炎症因子抗体局部雾化治疗支气管哮喘的实验研究[J]. 河北医科大学学报, 2016, 37(12): 1466-.
[13]	高洪芬. 240例哮喘患儿临床预后分析[J]. 河北医科大学学报, 2016, 37(11): 1337-1340.
[14]	项保利;汤建华;陈丽萍;李祯;胡亚丽;李艳云. 高渗盐雾化吸入治疗支气管扩张症的临床疗效观察[J]. , 2015, 36(8): 944-944.
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支气管哮喘患者外周血CD4+T、CD8+T、Th17、IL17表达水平与肺功能的相关性研究

Correlation between expression levels of CD4+T, CD8+T, Th17, IL17 and pulmonary functions in peripheral blood of patients with bronchial asthma#br#

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