GeneticpolymorphismofglutathioneS-transferasezeta1amonghealthy#br#
HanpopulationinHebeiprovince

doi:10.3969/j.issn.10073205.2016.02.003

Abstract

Abstract: Tostudythe glutathione S-transferasezeta1 ( GSTZ1 ) genetic
polymorphismsamonghealthyHanpopulationofHebeiprovince.Methods Usingpolymerase
chainreaction-restrictionfragmentlengthpolymorphism ( PCR-RFLP ) todetectthegenotypesof
GSTZ1Lys32Gluin210healthy Hanpopulationof Hebeiprovince.Results Thegenotype
distributionofthehealthy HebeiHanpopulationisconsistentwith Hardy-Weinberggenetic
equilibriumlaw.ThedistributionsofbothgenotypefrequencyandallelefrequencyofGSTZ1
Lys32Gluin Hebeihealthy Hanpopulationaresignificantlydifferentfrom thoseinIranian ,
Australian , GermanandAmerican ( P <0.05 ) .Thedistributionsofbothgenotypefrequencyand allelefrequency of GSTZ1 Lys32Gluin Iranian are significantly differentfrom thosein
Australian , Germanand American ( P <0.05 ), however , therearenosignificantdifference
amongAustralian , GermanandAmericaninthedistributionsofbothgenotypefrequencyand
allelefrequencyofGSTZ1Lys32Glu ( P >0.05 ) .Conclusion Thedistributionsofbothgenotype
frequencyandallelefrequencyofGSTZ1Lys32Gluin Hebeihealthy Hanpopulationownits
characters.ThedistributionsofGSTZ1Lys32Gluinregionsandracesaresignificantlydifferent.

Key words: gene , polymorphism , glutathione S-transferase zeta 1 , Hebei Han population

FANZhi-liang1,2,FENGXiao-juan 3,LIChun-yan 2,YINShao-hua1, TIANXin-ying 2*,REN Wen-bo. GeneticpolymorphismofglutathioneS-transferasezeta1amonghealthy#br# HanpopulationinHebeiprovince[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.02.003.

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GeneticpolymorphismofglutathioneS-transferasezeta1amonghealthy#br# HanpopulationinHebeiprovince

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